[INORG-10]Bismuth citrate as metal-organic framework for drug delivery

Anti-ulcer drug colloidal bismuth subcitrate (CBS) has a three-dimensional framework which shows diverse structures with different cations. In this study, CBS is proposed to be a drug carrying metal-organic framework (MOF). We elucidate the MOF concept by co-crystallization of CBS with cationic spermidine. Our crystallography data reveal the co-crystallization in two types of crystals with various pore sizes. It is found that spermidine acting as a guest molecule, can be diffused into the MOF structure and docked inside the channel via electrostatic interactions. We also demonstrate that CBS can carry small molecules such as metformin and isoniazid.

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[INORG-09]Photochromic barbiturate pendant-containing benzo[b]phosphole oxides with co-assembly property and photoinduced morphological changes

A series of novel barbiturate pendant-containing benzo[b]phosphole oxides has been demonstrated to exhibit photochromic and co-assembly properties. Both the open form and the photogenerated closed form of diarylethene-based benzo[b]phosphole oxides have displayed color changes upon addition of H-bonding ditopic receptor with formation of the supramolecular polymer. Moreover, both the unassembled and co-assembled states of the benzo[b]phosphole oxide have exhibited photoinduced coloration. Multiaddressable states of co-assembly mixture with multiple colors have been achieved via the combination of photochromism and thermochromism. More interestingly, photoinduced morphological changes from extensive porous network structures to ring-like aggregates have been observed for the co-assembly upon photoirradiation.

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[INORG-08]Solution-processable cyclometallated gold(III) complexes for high brightness phosphorescent white organic light-emitting devices

Two gold(III) complexes, Au-Y and Au-wY, have been tailor-made and utilized as emitters for solution-processed white organic light-emitting devices (WOLEDs). WOLEDs demonstrating high brightness of up to 10,000 cd m–2 and small efficiency roll-offs of less than 4% have been realized, which is anticipated to be due to the short-lived emission lifetime of <1 µs in both gold(III) complexes and a better carrier charge balance within the emitting layer.

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[INORG-07]Protamine-induced supramolecular self-assembly of red-emissive alkynylplatinum(II) 2,6-bis(benzimidazol-2′-yl)pyridine complex for selective label-free sensing of heparin and real-time monitoring of trypsin activity

A label-free detection assay for protamine is developed based on the supramolecular self-assembly of a new anionic alkynylplatinum(II) 2,6-bis(benzimidazol-2-yl)pyridine complex with the aid of electrostatic interaction and non-covalent metal–metal and π–π stacking interactions. This ensemble can also probe heparin by modulation of the self-assembly properties of platinum(II) complexes. In addition, the reported assay has been demonstrated to be a sensitive and selective detection method for trypsin as well as trypsin inhibitor screening, which is essential for drug discovery.

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[INORG-04]Neutral iridium(III) complexes tethered with a polyhedral oligomeric silsesquioxane nanocage for lipid droplet imaging and photodynamic therapy

The charge of a cellular reagent plays a significant role in the cell internalization and intracellular distribution, which is a prerequisite for theranostic applications. In this work, a new class of nonionic iridium(III) complexes tethered with a polyhedral oligomeric silsesquioxane (POSS) unit were synthesized and characterized for lipid droplet imaging and photodynamic therapy.

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[INORG-02] Utilization of rhenium(I) polypyridine complexes appended with a dinitrophenylsulfonyl moiety for bioimaging and photodynamic therapy

In this work, four rhenium(I) polypyridine complexes functionalized with a dinitrophenylsulfonyl (DNPS) moiety were designed for GSH-targeted imaging and photodynamic therapy. These complexes displayed weak emission due to efficient quenching by the DNPS unit. Upon reaction with intracellular GSH, the complexes showed substantial emission enhancement and time-dependent photocytotoxicity in HeLa cells.

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